By Dale J. Benos (Eds.)
Sodium reabsorbing epithelia play a tremendous position in whole-body sodium homeostasis. a few examples of sodium regulating tissues comprise kidney, colon, lung, and sweat ducts. Sodium shipping throughout those membranes is a two-step approach: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for shipping and are regulated through numerous assorted hormones. The sodium channels additionally play an important position in a few illness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and practical variety offers the 1st in-depth trade of principles referring to those sodium channels, their rules and involvement in common and pathophysiological events. Key beneficial properties * Summarizes present country of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal legislation of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * presents rules on sodium channels and disorder
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Extra info for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity
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1998). , 1996). , 1993). , 1998). In abENaC, four of the proposed consensus sites for PKCdependent phosphorylation are predicted to be intracellular. , 1993; Yanase and Handler, 1986). , 1996). , 1995). This observation 8 C. M. Fuller et al. may reflect a specific difference in how abENaC is regulated when expressed by itself; however, similar experiments on the chimeric bENaC/rENaC channel needed to address this question have not yet been performed. 111. THE C TERMINUS OF abENaC: A KINETIC SWITCH?