Amiloride-Sensitive Sodium Channels: Physiology and by Dale J. Benos (Eds.)

By Dale J. Benos (Eds.)

Sodium reabsorbing epithelia play a tremendous position in whole-body sodium homeostasis. a few examples of sodium regulating tissues comprise kidney, colon, lung, and sweat ducts. Sodium shipping throughout those membranes is a two-step approach: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for shipping and are regulated through numerous assorted hormones. The sodium channels additionally play an important position in a few illness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and practical variety offers the 1st in-depth trade of principles referring to those sodium channels, their rules and involvement in common and pathophysiological events. Key beneficial properties * Summarizes present country of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal legislation of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * presents rules on sodium channels and disorder

Show description

Read Online or Download Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity PDF

Similar basic sciences books

An Atlas of Induced Sputum: An Aid for Research and Diagnosis (Encyclopedia of Visual Medicine Series)

Containing greater than a hundred and fifty pictures of the very best quality, An Atlas of triggered Sputum: An reduction for study and prognosis is the 1st accomplished scientific advisor at the software of this diagnostic strategy to non-infectious inflammatory illnesses. The e-book contains contributions from best specialists during this speedily turning out to be box who have been members within the activity strength on brought about sputum backed by way of the eu breathing Society and chaired through the editors of this Atlas, Drs.

Fetal and Neonatal Physiology: Expert Consult - Online and Print, 2-Volume Set, 4e

Fetal and Neonatal body structure, edited through Drs. Polin, Fox, and Abman, specializes in physiologic advancements of the fetus and child and their effect at the medical perform of neonatology. A needs to for perform, this 4th variation brings you the newest details on genetic remedy, intrauterine infections, mind safety and neuroimaging, and lots more and plenty extra.

Pathophysiology of Disease: An Introduction to Clinical Medicine 7/E

A full-color, case-based assessment of the necessities of pathophysiology--covering all significant organs and structures The target of this depended on textual content is to introduce you to scientific drugs by means of reviewing the pathophysiologic foundation of one hundred twenty ailments (and linked signs) often encountered in clinical perform.

Extra info for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

Sample text

1997). Functional effects of mutations in the membrane spanning regions of the a-subunit of the amiloridesensitive Na' channel (ENaC). Physiologist 40, A-7 (abstr. 6). , Sorscher, E. , Ausiello, D. , and Benos, D. J. (1989). Immunocytochemical localization of Na' channels in rat kidney medulla. Am. J . Physiol. 256, F366-F369. Bubien, J. , Ismailov, I. , Berdiev, B. , Lifton. R. , Fuller, C. , Achard, J. , Benos, D. , and U'arnock, D. G . (1996). Liddle's disease: Abnormal regulation of amiloride-sensitive Na' channels by p-subunit mutation.

J. Physiol. 265, C224-C233. Price, M. , Snyder, P. , and Welsh, M. J. (1996). Cloning and expression of a novel human brain Na' channel. J . Biol. Chem. 271,7879-7882. Rouch, A. , Kudo, L. , Bell, P. , Fowler, B. , Corbitt, B. , and Schafer, J. A. (1993). Intracellular Ca" atid PKC activation do not inhibit Na' and water transport in the rat CCD. Am. J. Physiol. 265, F569-F577. , and Benos, D. J. (1986). Detergent solubilization, functional reconstitution, and partial purification of an epithelial amiloride-binding protein.

1998). , 1996). , 1993). , 1998). In abENaC, four of the proposed consensus sites for PKCdependent phosphorylation are predicted to be intracellular. , 1993; Yanase and Handler, 1986). , 1996). , 1995). This observation 8 C. M. Fuller et al. may reflect a specific difference in how abENaC is regulated when expressed by itself; however, similar experiments on the chimeric bENaC/rENaC channel needed to address this question have not yet been performed. 111. THE C TERMINUS OF abENaC: A KINETIC SWITCH?

Download PDF sample

Rated 4.10 of 5 – based on 9 votes