Animal Lectins: A Functional View by Gerardo R. Vasta PhD, Hafiz Ahmed PhD

By Gerardo R. Vasta PhD, Hafiz Ahmed PhD

Introduces Groundbreaking techniques for Assessing Lectin Function

Lectins and their ligands are less than fairly a heavy microscope because of their strength functions to pharmacology, immunology, melanoma treatment, and agriculture. With growing to be curiosity within the glycobiology box, the physique of study regarding lectin roles has grown at an explosive price, relatively long ago twenty years. Animal Lectins: A sensible View offers the main up to date research of those carbohydrate-binding, and almost certainly lifesaving, proteins in a single accomplished quantity.

This standard-setting source offers new insights into the organic roles of such a lot animal lectins, together with their functionality in an infection prevention via innate immunity. It additionally discusses such lectin behaviors as:

  • Glycoprotein folding
  • Sorting and targeting
  • Cell adhesion
  • Embryogenesis
  • Cell-cell interactions and signaling

Describes the Structural foundation of Protein-Carbohydrate Interactions

Under the editorial assistance of 2 best protein chemistry specialists and with contributions from well-recognized box experts, this publication logically and systematically discusses either intracellular and extracellular lectin services. it's a vital springboard for destiny box study and a transparent and concise wisdom base that glycobiology, biochemistry, and immunology researchers can't have enough money to be without.

Show description

Read Online or Download Animal Lectins: A Functional View PDF

Best developmental biology books

The X in Sex: How the X Chromosome Controls Our Lives

How will we turn into male or lady? The X in intercourse: How the X Chromosome Controls Our Lives, by means of David Bainbridge writes a compelling and stress-free e-book that explains the X and Y Chromosomes having a profound influence on our lives, picking what intercourse we'll be and likewise influencing how we are living. Bainbridge takes readers right into a neat over view of the X chromosome, pointing out its significance within the genetic make-up of the individual.

Rise and Fall of Epithelial Phenotype: Concepts of Epithelial-Mesenchymal Transition (Molecular Biology Intelligence Unit)

Epithelial phenotype is a dynamic level of differentiation that may be modulated in the course of a number of physiological or pathological occasions. The quick conversion to a mesenchymal-like phenotype is named an epithelial-mesenchymal transition (EMT). the increase and Fall of Epithelial Phenotype is the 1st ebook to comprehensively introduce the idea that of EMT.

Sex, Reproduction and Darwinism

This selection of essays appears to be like at sexuality and replica from an evolutionary viewpoint. overlaying experimental discoveries in addition to theoretical investigations, the quantity explores the connection among evolution and different parts of human behaviour.

The Cadherin Superfamily: Key Regulators of Animal Development and Physiology

This e-book provides an summary of the whole box of cadherin study and gives the present easy idea of cadherins. Cadherins were broadly accredited as key regulators of animal improvement and physiological capabilities, and it additionally has develop into transparent that they play crucial roles in a number of human illnesses.

Extra resources for Animal Lectins: A Functional View

Sample text

Nature 169, 825–826. 11. J. M. 1968 Isolation and characterization of a hemagglutinin from Limulus polyphemus. J. Mol. Biol. 32, 453–465. 12. Hammarstrom, S. A. 1969 Purification and characterization of a blood-group A reactive hemagglutinin from the snail Helix pomatia and a study of its combining site. Biochemistry 8, 2696–2705. indd 8 9/1/2008 5:59:35 PM Introduction to Animal Lectins 9 13. F. R. 1971 Monosaccharides as specific precipitinogens of eel anti-human blood group H (O) antibody. Biochemistry 10, 3749–3760.

1 Lectin Families Lectin Family Cation C-type S-type (Galectins) Yes No F-type I-type (singlecs) P-type (Man-6-P) R-type Yes No Variable No Others Families Heparin-binding type Pentraxins No Most Carbohydrate Specificity Man, Gal, Fuc (Variable) β-galactosides Fucose Sia (Variable) Mannose-6-P Defining Features C-type sequence motif S-type sequence motif β-Galactosides F-type sequence motif Ig-like domains P-type sequence motif R-type sequence motif Heparin/heparan-(SO4)2− PC/galactosides Basic amino acid clusters Pentameric repeats PC, phosphoryl-choline.

USA 72, 1383–1387. 16. I. J. 1965 Specific binding of concanvalin A to cross-linked dextran gels. Biochem. J. 96, 23C–25C. 17. M. 2001 The ABO blood group system: Historical background. Transfus. Med. 11, 243–265. 18. Kocourek, J. 1986 Historical background. J. ), The Lectins: Properties, Functions and Applications in Biology and Medicine. Academic Press, Orlando, FL, pp. 1–32. 19. Sharon, N. and Lis, H. 2004 History of lectins: From hemagglutinins to biological recognition molecules. Glycobiology 14, 53R–62R.

Download PDF sample

Rated 4.05 of 5 – based on 26 votes