By Gerardo R. Vasta PhD, Hafiz Ahmed PhD
Introduces Groundbreaking techniques for Assessing Lectin Function
Lectins and their ligands are less than fairly a heavy microscope because of their strength functions to pharmacology, immunology, melanoma treatment, and agriculture. With growing to be curiosity within the glycobiology box, the physique of study regarding lectin roles has grown at an explosive price, relatively long ago twenty years. Animal Lectins: A sensible View offers the main up to date research of those carbohydrate-binding, and almost certainly lifesaving, proteins in a single accomplished quantity.
This standard-setting source offers new insights into the organic roles of such a lot animal lectins, together with their functionality in an infection prevention via innate immunity. It additionally discusses such lectin behaviors as:
- Glycoprotein folding
- Sorting and targeting
- Cell adhesion
- Cell-cell interactions and signaling
Describes the Structural foundation of Protein-Carbohydrate Interactions
Under the editorial assistance of 2 best protein chemistry specialists and with contributions from well-recognized box experts, this publication logically and systematically discusses either intracellular and extracellular lectin services. it's a vital springboard for destiny box study and a transparent and concise wisdom base that glycobiology, biochemistry, and immunology researchers can't have enough money to be without.
Read Online or Download Animal Lectins: A Functional View PDF
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Extra resources for Animal Lectins: A Functional View
Nature 169, 825–826. 11. J. M. 1968 Isolation and characterization of a hemagglutinin from Limulus polyphemus. J. Mol. Biol. 32, 453–465. 12. Hammarstrom, S. A. 1969 Purification and characterization of a blood-group A reactive hemagglutinin from the snail Helix pomatia and a study of its combining site. Biochemistry 8, 2696–2705. indd 8 9/1/2008 5:59:35 PM Introduction to Animal Lectins 9 13. F. R. 1971 Monosaccharides as specific precipitinogens of eel anti-human blood group H (O) antibody. Biochemistry 10, 3749–3760.
1 Lectin Families Lectin Family Cation C-type S-type (Galectins) Yes No F-type I-type (singlecs) P-type (Man-6-P) R-type Yes No Variable No Others Families Heparin-binding type Pentraxins No Most Carbohydrate Speciﬁcity Man, Gal, Fuc (Variable) β-galactosides Fucose Sia (Variable) Mannose-6-P Deﬁning Features C-type sequence motif S-type sequence motif β-Galactosides F-type sequence motif Ig-like domains P-type sequence motif R-type sequence motif Heparin/heparan-(SO4)2− PC/galactosides Basic amino acid clusters Pentameric repeats PC, phosphoryl-choline.
USA 72, 1383–1387. 16. I. J. 1965 Specific binding of concanvalin A to cross-linked dextran gels. Biochem. J. 96, 23C–25C. 17. M. 2001 The ABO blood group system: Historical background. Transfus. Med. 11, 243–265. 18. Kocourek, J. 1986 Historical background. J. ), The Lectins: Properties, Functions and Applications in Biology and Medicine. Academic Press, Orlando, FL, pp. 1–32. 19. Sharon, N. and Lis, H. 2004 History of lectins: From hemagglutinins to biological recognition molecules. Glycobiology 14, 53R–62R.