By Linda A. Felton, James W. McGinity
Aqueous-based movie coating has develop into regimen within the pharmaceutical undefined. This procedure removes using natural solvents and hence avoids financial, environmental, and toxicological concerns relating to residual solvents and solvent restoration. Aqueous-based coating, in spite of the fact that, is advanced and lots of variables could influence the ultimate product and its functionality. This fourth version of Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms goals to supply perception into the standards and parameters that are meant to be thought of and regulated for the winning improvement and commercialization of a covered product.
The fourth variation has been revised and extended to mirror the newest clinical developments from the literature. The contributing authors clarify intimately, utilizing illustrated examples, applicable steps to unravel and preferably stay away from formula, processing, and balance difficulties and to accomplish an optimized dosage shape. alternate names and chemical names of commercially advertised coatings are used during the textual content to assist familiarize the reader with a number of the fabrics on hand for pharmaceutical purposes. This e-book might be a useful source for a person within the pharmaceutical operating within the zone of aqueous-based movie coating.
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Extra info for Aqueous polymeric coatings for pharmaceutical dosage forms
The release patterns for coated beads were analyzed for two model drug systems: phenylpropanolamine (PPA) HCl and anhydrous theophylline. Aquacoat® ECD was applied at various levels and the in vitro drug-release rate was shown to be inversely proportional to film loading (thickness), suggesting that constant drug diffusion through the film is maintained. Such zero-order release is characteristic of a reservoir and rate-limiting barrier as long as a concentration gradient is maintained in the bead.
APPLICATIONS DATA As shown in the following list, variables that greatly affect the release-rate profiles through a pseudolatex film relate to both the substrate and the drug physicochemical characteristics, most notably solubility. The release patterns for coated beads were analyzed for two model drug systems: phenylpropanolamine (PPA) HCl and anhydrous theophylline. Aquacoat® ECD was applied at various levels and the in vitro drug-release rate was shown to be inversely proportional to film loading (thickness), suggesting that constant drug diffusion through the film is maintained.
TEC, triethyl citrate. -X. Li, B. A. Carlin, J. T. 14. Curing can be carried out by oven heating or in situ heating in a fluid-bed coater using increased fluidization to avoid pellet agglomeration. Coating is normally carried out below the Tg of the film to minimize tackiness, especially under the low bulk fluidization conditions in the slowly percolating pellet bed outside the Wurster column. , Opadry®) watersoluble polymer top coating can be applied to enable low fluidization curing above the Tg.