By Cui D. et al.
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Extra resources for Atlas of Histology with Functional and Clinical Correlations
SIMPLE CUBOIDAL EPITHELIUM is composed of one layer of uniform cuboidal cells, which rest on the basement membrane (Figs. 3-5A,B and 3-6A,B). The cell’s height, width, and depth are roughly equal. Nuclei are centrally placed and spherical in shape. Some cuboidal cells have long and abundant microvilli, which form a brush border on their apical surfaces. Such cells are found in the proximal tubules of the kidney. Other cuboidal cells have few, short microvilli which do not form a brush border; these cells can be found in the distal and collecting tubules of the kidney.
This type of epithelium protects the body against injury, abrasion, dehydration, and infection. This epithelium may be keratinized or nonkeratinized, depending on functional demands (Figs. 3-13A,B and 3-14A,B). Keratinized stratiﬁed squamous epithelium is found in the skin. The top layers consist of either thick or thin keratinized cells (ﬂattened, nonnucleated dead cells) that are ﬁlled with tonoﬁlaments. The thickness of the stratiﬁed squamous epithelium varies from region to region. Nonkeratinized stratiﬁed squamous epithelium is similar to keratinized squamous epithelium except that surface cells are nucleated instead of nonnucleated.
The eosinophilia (acidophilia) of the cytoplasm is largely attributable to the abundance of mitochondria. Steroid hormone–secreting cells vary in the amount of cholesterol stored in the form of lipid droplets, which appear in most preparations as empty vacuoles because their contents are extracted during specimen preparation. The cells in the main panel are in the zona reticularis and have few droplets, similar to the cell in the electron micrograph (Fig. 2-10A). The cells in the inset are from the zona fasciculata and have numerous lipid droplets.