By MD Frank H. Netter
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Additional info for Atlas of Neuroanatomy and Neurophysiology
The nucleus responds to various stimuli at particular times and in specific ways. Specific movements and forces act as regions differentiate. The forces act in regions named metabolic fields. New terms were needed to describe the unique forces acting in each field. Eight late metabolic fields were discovered where specific tissues differentiate from either mesenchyme or epithelium. The name of each field and the specific tissue that arises are as follows: condensation = mesenchymal condensation; contusion = precartilage; distussion = cartilage; dilation = muscle; retension = fibrous tissue; detraction = bone; corrosion = epithelial breakdown; and parathelial loosening = glands.
During in vitro fertilization, capacitation is induced by incubating the sperms in a defined medium for several hours (see Fig. 2-15). Completion of capacitation permits the acrosome reaction to occur. The acrosome of the capacitated sperm binds to a glycoprotein (ZP3) on the zona pellucida (Fig. 2-13A and B). Studies have shown that the sperm plasma membrane, calcium ions, prostaglandins, and progesterone play a critical role in the acrosome reaction. This reaction of sperms must be completed before the sperms can fuse with the oocyte.
In anovulatory cycles, the endometrial changes are minimal; the proliferative endometrium develops as usual, but ovulation does not occur and no corpus luteum forms. Consequently, the endometrium does not progress to the luteal phase; it remains in the proliferative phase until menstruation begins. Anovulatory cycles may result from ovarian hypofunction. The estrogen, with or without progesterone, in oral contraceptives (birth control pills) acts on the hypothalamus and pituitary gland, resulting in inhibition of secretion of gonadotropin-releasing hormone, FSH, and LH, the secretion of which is essential for ovulation to occur.