Basic Nephrology and Acute Kidney Injury by M. Sahay

By M. Sahay

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Inulin was obviously considered as a safe product with any effect on GFR (Shannon, 1934). Inulin is freely filtrated through a semi-permeable membrane which is a strong argument for the absence of binding to protein. , 1937). , 1937). The absence of both tubular absorption and secretion has been demonstrated by an important article published by Shannon in 1934 (Shannon, 1934). In this article, this author showed the 24 Basic Nephrology and Acute Kidney Injury absence of inulin excretion in two types of aglomerular fishes (goosefish, Lophius piscatorius and toadfish Osteichthyes - Lophiidae).

This aspect has been debated in the literature. , 2001). , 1983; Kempi & Persson, 1975). This hypothesis has been well illustrated in 1980 by Carlsen who studied and compared 51Cr-EDTA clearances with 4 different commercial preparations of 99Tc-DTPA. , 1980). , 1990). , 2001). , 1990). Another potential critic about 99Tc-DTPA is the very poor available data on its physiological handling. , 1972). 2 Clinical data There are hopefully much more clinical studies comparing 99Tc-DTPA with other markers.

1990). Another potential critic about 99Tc-DTPA is the very poor available data on its physiological handling. , 1972). 2 Clinical data There are hopefully much more clinical studies comparing 99Tc-DTPA with other markers. , 1970), the performances of 99Tc-DTPA clearance was studied from the seventies. , 1972). , 1980). , 1984). In table 3, we resumed the results of studies comparing 99Tc-DTPA with the gold standard method in adults. Two studies have compared with good statistical methods the urinary clearance of 99Tc-DTPA and inulin.

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