By Martinez J. Hewlett, David C. Bloom, David Camerini Edward K. Wagner
Excellent for the scholar looking an excellent figuring out of the fundamental ideas during this quickly constructing box, this best-selling textual content bargains a accomplished advent to the basics of virology. that includes an stronger paintings software now in full-color, the hot version has been up-to-date all through. re-creation accommodates extra studying feedback, increased assessment questions, bankruptcy outlines and full-colour paintings includes new chapters facing viruses and melanoma, new release and use of recombinant viruses and virus-like debris, viral evolution, community biology and viruses, and animal versions and transgenics, in addition to a bankruptcy dedicated to HIV and AIDS Downloadable art, unique animations and on-line assets can be found at www.blackwellpublishing.com/wagner
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Extra info for Basic Virology, 3rd Edition
The most basic molecular requirement for virus replication is for virus to induce either profound or subtle changes in the cell so that viral genes in the genome are replicated and viral proteins are expressed. This will result in the formation of new viruses – usually many more than the number of viruses infecting the cell in the first place. When reproducing, viruses use at least part of the cell’s equipment for replication of viral nucleic acids and expression of viral genes. They also use the cell’s protein synthetic machinery, and the cell’s metabolic energy resources.
This response often leads to partial or complete immunity to reinfection. The study of these processes was instrumental to gaining an increasingly clear understanding of the immune response and the precise molecular nature of cell–cell signaling pathways. It also provided therapeutic and preventive strategies against specific virus-caused disease. The study of virology has and will continue to provide strategies for the palliative treatment of metabolic and genetic diseases not only in humans, but also in other economically and aesthetically important animal and plant populations.
We would especially like to acknowledge Dr. Luis Villareal and the Center for Virus Research at the University of California, Irvine, for supporting our efforts in bringing this book to a timely completion. Virology and Viral Disease ✷ ✷ ✷ ✷ ✷ ✷ Introduction – the Impact of Viruses on Our View of Life ✷ The Science of Virology An Outline of Virus Replication and Viral Pathogenesis ✷ Virus Replication ✷ Pathogenesis of Viral Infection Virus Disease in Populations and Individual Animals ✷ The Nature of Virus Reservoirs ✷ Viruses in Populations ✷ Animal Models to Study Viral Pathogenesis Patterns of Some Viral Diseases of Humans ✷ The Dynamics of Human–Virus Interactions ✷ Patterns of Speciﬁc Viral Diseases of Humans ✷ Some Viral Infections Targeting Speciﬁc Organ Systems Problems for Part I Additional Reading for Part I P A R T I Introduction – The Impact of Viruses on Our View of Life CHAPTER ✷ THE SCIENCE OF VIROLOGY ✷ The effect of virus infections on the host organism and populations – viral pathogenesis, virulence, and epidemiology ✷ The interaction between viruses and their hosts ✷ The history of virology ✷ Examples of the impact of viral disease on human history ✷ Examples of the evolutionary impact of the virus–host interaction ✷ The origin of viruses ✷ Viruses have a constructive as well as destructive impact on society ✷ Viruses are not the smallest self-replicating pathogens ✷ QUESTIONS FOR CHAPTER 1 THE SCIENCE OF VIROLOGY The study of viruses has historically provided and continues to provide the basis for much of our most fundamental understanding of modern biology, genetics, and medicine.