Calcium - A Medical Dictionary, Bibliography, and Annotated by Icon Health Publications, Health Publica Icon Health

By Icon Health Publications, Health Publica Icon Health Publications

It is a 3-in-1 reference publication. It supplies a whole clinical dictionary masking hundreds of thousands of phrases and expressions in relation to calcium. It additionally offers large lists of bibliographic citations. ultimately, it offers details to clients on the way to replace their wisdom utilizing a variety of net assets. The publication is designed for physicians, scientific scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to get to grips with study devoted to calcium. in case your time is effective, this ebook is for you. First, you won't waste time looking the web whereas lacking loads of proper details. moment, the publication additionally saves you time indexing and defining entries. ultimately, you won't waste time and cash printing enormous quantities of web content.

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Professor of Medicine; Medicine; Dartmouth College 11 Rope Ferry Rd. #6210 Hanover, NH 03755 Timing: Fiscal Year 2001; Project Start 30-SEP-1988; Project End 31-DEC-2003 Summary: This application, a resubmission for the renewal of "Calcium Prevention of Neoplastic Polyps," is a proposal to collect further information on subjects in our randomized, placebo-controlled trial of calcium supplementation for the prevention of colorectal adenomas. The study began in response to animal and human experimental data and some epidemiological findings suggesting that calcium intake may exert a protective effect on large bowel neoplasia.

As well, animal models and some epidemiological data suggest that vitamin D may protect against bowel carcinogenesis. We propose to investigate this in the context of our trial, and to examine polymorphisms in the vitamin D receptor gene. With the funds requested here, we will use our established subject population and available biological specimens to study these mechanisms. We will follow the subjects in the study until the year 2003, monitor their medical history, and track adenoma recurrence after the end of treatment in the trial.

The specific aims are to determine (1) the molecular basis for the Ca/CaM stimulated PLA2 and (2) how the Ca/CaM PLA2 affects the Na,K-ATPase. The results will define a new Ca/CaM-PLA2 capable of participating in cell signaling and of regulating Na,K-ATPase in response to changes intracellular free calcium. The studies will be carried out in red cells due to their advantages as a simple model system, but should be applicable to other cells, including neurons, where Na,K-ATPase is also inhibited by changes in intracellular free calcium.

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