Cardiac Mechanics and Function in the Normal and Diseased by Eduardo Marban (auth.), Dr. Masatsugu Hori, Dr. Hiroyuki

By Eduardo Marban (auth.), Dr. Masatsugu Hori, Dr. Hiroyuki Suga, Prof. Jan Baan, Prof. Edward L. Yellin (eds.)

Cardiovascular dynamics is a box during which modelling and platforms research have shaped an exceptionally very important self-discipline. for instance, knowing of even this type of basic functionality of the circulate because the courting among crucial venous strain apd cardiac output has required evolution of a pertinent version in line with years of exhaustive ex­ perimental investigations through Starling, Starr, and Guyton. Hemodynamic analyses of pulsatile pressures and flows within the arteries and veins were a continual problem taken up via champions of fluid dynamics corresponding to Frank, Wetterer, Taylor, and Wormersley, simply to point out a number of names, and a few type of version was once regularly proposed as a conceptual framework. an excellent better problem to cardiovascular dynamicists was once find out how to research the intermittent coupling of the ventricle and the arterial or venous vasculature during the valve. the supply of numerical suggestions via computing device and the lately advanced ventricular version with a time-varying elastance and a pressure-dependent inner resistance opened the best way to research of this coupling. The ever­ expanding pace of pcs has additionally facilitated journeys among the fre­ quency and the time area, even online for a few experimental reports. This booklet comprises many analyses devoted to the interactions among the center and the vasculature, offering the reader with findings on the leading edge of present examine during this field.

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Extra resources for Cardiac Mechanics and Function in the Normal and Diseased Heart

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Whether or not such extreme cooperativity in molecular motion is possible is open to discussion. --- -54 -----.. -......... r-- t-.... w o II: oLI. 5 50 500 FREQUENCY (Hz) Fig. 5. Active force fluctuation spectrum expected from cross-bridge cycling during contraction. 1 mg (w). -100 dB = 1 ng (w). div. division -54 I t-:-- ! ~...... ' -.. ~ w ~. oII: o U. ,J\. J.. ~ I!. 5 50 500 FREQUENCY (Hz) Fig. 6. Actually measured force fluctuations during rest (broken curve) and during contraction (solid curve).

Since the time course of tension transient in response to small step length changes has been reported to be independent of activation level [1, 7], the rate of cross-bridge cycling appear to be insensitive to the changes in activation level under quasi-isometric conditions where the shortening activation is likely to be less prominent. All the activation level dependences of the segment lengtii response observed in chemically skinned preparations, described here, were also observed in the muscle in Ba2 + contracture.

The profiles of segment length response were quite similar to those of the muscle in Ba2 + contracture, indicating that these oscillatory segment length responses are not peculiar characteristics observed only in muscle activated with Ba2 +. This is quite consistent with our previous finding [7] that the transient tension responses for step length perturbations of Ba2 +-activated glycerinated cardiac muscle are similar to those of Ca2 +-activated glyceripated cardiac muscle. The significant differences between the segment and muscle length response and the length dependence of the segment length transients, which were observed in the muscle in Ba2+ contracture and described in the previous section, were also observed in this chemically skinned preparation.

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