Chemical Approaches to Brain Function by S. Ehrenpreis

By S. Ehrenpreis

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In "The Neurosciences: Second Study Program" ( F . O. Schmitt, e d . ) , p . 8 1 2 . Rockefeller U n i v . Press, N e w York. Shooter, Ε . , and Varon, S. ( 1 9 7 0 ) . In "Protein Metabolism of the Nervous Silberstein, S. D . , J o h n s o n , D . G . , H a n b a u e r , I . , a n d K o p i n , I. J . ( 1 9 7 1 a ) . Pharma­ S y s t e m " ( A . L a j t h a , e d . ) , p . 4 1 9 . P l e n u m , N e w York. cologist 13, 203. Silberstein, S. D . , J o h n s o n , D . G . , J a c o b o w i t z , D .

Phar­ macol. 2 0 , 3 0 8 . Vogt, M . ( 1 9 5 4 ) . / . Physiol. 1 2 3 , 4 5 1 . W e i s e n b e r g , R. C . , Borisey, C . , a n d T a y l o r , E . W . ( 1 9 6 8 ) . Biochemistry 7, 4 4 6 6 . Y a m a d a , Κ. M . , a n d Wessells, Ν. K . ( 1 9 7 1 ) . Exp. Cell. Res. 66, 3 4 6 . THE DEVELOPMENT OF CATECHOLAMINERGIC NEURONS OF THE CENTRAL NERVOUS SYSTEM 1 Joseph T. Coyle LABORATORY OF CLINICAL SCIENCE, NATIONAL INSTITUTE OF MENTAL HEALTH, BETHESDA, MARYLAND I. II. III. IV. Introduction H i s t o g e n e s i s of the C a t e c h o l a m i n e r g i c N e u r o n s .

Functional Aspects of Developing Catecholaminergic Neurons Information about the development of the catecholaminergic receptors in the central nervous system of the rat is sparse. Woodward et al. (1971) have examined the electrical responses of rat cerebellar Purkinje neurons to various chemical stimuli before, during, and after the forma­ tion of synapses. The spontaneous activity of Purkinje cells is inhibited by microiontophoretically applied norepinephrine and its possible "sec­ ond messenger," adenosine cyclic monophosphate, before as well as after synaptogenesis.

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